Journal article
Interaction between HIF-1α (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1α
FEBS letters, v 579(28), pp 6428-6432
21 Nov 2005
PMCID: PMC4505811
PMID: 16288748
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Hypoxia inducible factor-1α (HIF-1α) is a central component of the cellular responses to hypoxia. Hypoxic conditions result in stabilization of HIF-1α and formation of the transcriptionally active HIF-1 complex. It was suggested that mammalian ARD1 acetylates HIF-1α and thereby enhances HIF-1α ubiquitination and degradation. Furthermore, ARD1 was proposed to be downregulated in hypoxia thus facilitating the stabilization of HIF-1α. Here we demonstrate that the level of human ARD1 (hARD1) protein is not decreased in hypoxia. Moreover, hARD1 does not acetylate and destabilize HIF-1α. However, we find that hARD1 specifically binds HIF-1α, suggesting a putative, still unclear, connection between these proteins.
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Details
- Title
- Interaction between HIF-1α (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1α
- Creators
- Thomas Arnesen - University of BergenXianguo Kong - Thomas Jefferson UniversityRune Evjenth - University of BergenDarina Gromyko - University of BergenJan Erik Varhaug - Haukeland University HospitalZhao Lin - Thomas Jefferson UniversityNianli Sang - Thomas Jefferson UniversityJaime Caro - Thomas Jefferson UniversityJohan R. Lillehaug - University of Bergen
- Publication Details
- FEBS letters, v 579(28), pp 6428-6432
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000233520700022
- Scopus ID
- 2-s2.0-27744450043
- Other Identifier
- 991021211720404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics
- Cell Biology